We are looking for a knowledgeable Bioinformatician to aid establish and lead the computational side of a new, expanding group.
The Crossley study team ( https://www.cruk.cam.ac.uk/research-groups/crossley-group/ researches RNA-DNA hybrid molecules called R-loops – just how they are dysregulated in human condition, drive genome instability and inflammation, and just how these particles and mobile responses to them can be taken advantage of for cancer discovery and therapy. We make use of biochemical, imaging and genomics approaches to research molecular systems underlying R-loop biology and their professional applications.
You will lead computational projects, construct and enhance information evaluation pipelines and team up with and advisor group members. The job will concentrate generally on the evaluation of massive genomics datasets, mostly RNA-DNA hybrid sequencing (mobile and extracellular) and RNA/ChIP/ATAC-seq, to sustain our exploration and translational study. A deep understanding of biological principles is crucial, to produce hypotheses and mechanistic understanding from our data and help overview speculative design.
You will certainly have a Master’s or PhD in Bioinformatics (or related field) and comprehensive experience, consisting of a selection of programming languages and platforms, evaluation of genomics datasets in a scholastic setup, and a robust understanding of statistics. Solid critical thinking and freedom is needed, to deal with first-in-class sequencing information from RNA-DNA hybrids from organic and clinical examples, and to help develop new hybrid sequencing methods (e.g. single-cell and long-read).
As the bioinformatics lead of a new research group, a desire and capability to set up efficient and resilient bioinformatics codebases, consisting of version control and reproducible analysis pipelines, is vital. Experience with and readiness to leverage and build upon existing open-source remedies is very desirable. You will work collaboratively with Dr. Crossley and various other group members who will create sequencing information, and lead communications with computational and AI researchers and bioinformaticians in various other research study teams, and the bioinformatics core facility.
Fixed-term: The funds for this post will certainly be readily available for 2 years in the first circumstances, with the opportunity to expand.
When a deal of work has actually been accepted, the effective candidate will be needed to undergo a basic disclosure (criminal records inspect) check and a protection check.
If you have any questions regarding the application procedure or questions connecting to this openings, please get in touch with: [email protected]
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Please consist of information of your referees, including e-mail address and contact number, one of which have to be your newest line manager.
Closing day: 21 st September 2025
Meetings are anticipated to occur on or around 1 st October.
For details regarding just how your personal information is used as a candidate, please see the section on Candidate Information ( https://www.hr.admin.cam.ac.uk/hr-staff/hr-data/applicant-data on our human resources website.
Please quote reference SW 47115 on your application and in any communication concerning this vacancy.
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